We present a new tweakable block cipher family SKINNY, whose goal is to compete with NSA recent design SIMON in terms of hardware/software performances, while proving in addition much stronger security guarantees with regards to differential/linear attacks. In particular, unlike SIMON, we are able to provide strong bounds for all versions, and not only in the single-key model, but also in the related-key or related-tweak model. SKINNY has flexible block/key/tweak sizes and can also benefit from very efficient threshold implementations for side-channel protection. Regarding performances, it outperforms all known ciphers for ASIC round-based implementations, while still reaching an extremely small area for serial implementations and a very good efficiency for software and micro-controllers implementations (SKINNY has the smallest total number of AND/OR/XOR gates used for encryption process). Secondly, we present MANTIS, a dedicated variant of SKINNY for low-latency implementations, that constitutes a very efficient solution to the problem of designing a tweakable block cipher for memory encryption. MANTIS basically reuses well understood, previously studied, known components. Yet, by putting those components together in a new fashion, we obtain a competitive cipher to PRINCE in latency and area, while being enhanced with a tweak input.